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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Sci Signal. 2016 Aug 16;9(441):ra80. doi: 10.1126/scisignal.aaf3204

Fig. 6. Intermittent hypoxia activates H2S signaling in the carotid body.

Fig. 6

Intermittent hypoxia (IH) induces ROS-dependent inhibition of CO production by HO-2, which leads to decreased PKG activity and increased H2S production by CSE that triggers the carotid body chemosensory reflex, leading to sympathetic activation and hypertension.