Table 1.

Demographic, Clinical, and Thyroid Function Variables in the Low-Normal TSH and High-Normal TSH Groups

Measures	Low-Normal TSH (n = 88)	High-Normal TSH (n = 52)	P Value
Age, y	48.9 ± 1.2a	49.5 ± 1.8	0.75
Sex	93% female	87% female	0.24
	7% male	13% male
Estrogen status	43% prenone	47% prenone	0.89
	11% preon	9% preon
	41% postnone	42% postnone
	5% poston	2% poston
L-T4 time,b y	12.4 ± 1.1	10.7 ± 1.1	0.26
L-T4 dose time,c y	1.64 ± 0.23	2.24 ± 0.43	0.22
L-T4 dose, μg/kg	1.51 ± 0.05d	1.24 ± 0.06	0.001
TSH, mU/L	1.36 ± 0.07	3.73 ± 0.12	<0.0001
fT4, ng/dL	1.68 ± 0.04	1.57 ± 0.05	0.09
fT3, pg/dL	215 ± 5	209 ± 6	0.49
fT3/fT4 ratio, pg/ng	136 ± 5	137 ± 5	0.81
Heart rate, beats/min	68.0 ± 1.2	70.9 ± 1.7	0.16
Systolic blood pressure, mm Hg	116.4 ± 1.6	116.7 ± 2.3	0.90
Diastolic blood pressure, mm Hg	68.2 ± 0.9	71.6 ± 2.5	0.20

Abbreviations: Preon, premenopausal on hormone treatment; prenone, premenopausal, no hormone treatment; poston, postmenopausal on hormone treatment; postnone, postmenopausal, no hormone treatment.

^aValues are means ± SEM.

^bDuration of L-T4 therapy.

^cDuration of current L-T4 dose.

^dSignificant differences between groups are shown in bold with corresponding P values.