Table 3.

Multivariable Cox Regression Model Fits for POI

	POI (n = 100)
Characteristic	N	na	%	HR	CI	P Value
Age at cancer diagnosis (years)b
Mean (SD)	8.10 (5.57)			0.97	0.92–1.02	0.28
Oophoropexy
No	863	80	9.27	1.00
Yes	58	20	34.48	1.33	0.70–2.53	0.39
Body mass index
≥18.5–24.9 kg/m2	338	42	12.43	1.00
<18.5 kg/m2	43	12	27.91	1.52	0.71–3.23	0.28
25–29.9 kg/m2	224	29	12.95	0.93	0.54–1.61	0.80
≥30 kg/m2	316	17	5.38	0.43	0.22–0.86	0.02
Ovarian radiation dose
None	72c	10	1.39	1.00
>999 cGy	86c	29	27.36	13.85	6.50–29.51	<0.001
≥1000 cGy	79c	44	74.58	132.34	62.88–278.53	<0.001
CED
0 mg/m2	379	19	5.01	1.00
< 8000 mg/m2	251	32	12.75	1.55	0.77–3.11	0.10
8000–11,999 mg/m2	164	16	9.76	2.77	1.18–6.51	0.02
12,000–19,999 mg/m2	86	24	27.91	3.90	1.80–8.43	0.001
≥20,000 mg/m2	41	9	21.95	4.13	1.63–10.50	0.003

^a Number of patients with POI with each characteristic.

^b Variable was included in the model as continuous.

^c Radiation dose data missing on 35 patients.