Table 4.

Multivariable Cox Regression Model Fits for POI After Combining Treatment Modalities

	POI (n = 100)
Characteristic	N	n a	%	HR	CI	P Value
Age at cancer diagnosis (years)b
Mean (SD)	8.10 (5.57)			1.02	0.98–1.06	0.41
Oophoropexy
No	863	80	9.27	1.00
Yes	58	20	34.48	0.72	0.42–1.23	0.23
Body mass index
≥18.5–24.99 kg/m2	338	42	12.43	1.00
<18.5 kg/m2	43	12	27.91	1.87	0.97–3.59	0.06
25.0–29.9 kg/m2	224	29	12.95	0.92	0.56–1.52	0.74
≥30 kg/m2	316	17	5.38	0.36	0.20–0.65	0.001
Treatment exposure
No alkylating agent nor ovarian radiotherapy	318c	2	0.63	1.00
Alkylating agent only	400c	8	2.00	2.98	0.63–14.06	0.17
Ovarian radiotherapy only	59c	17	28.81	71.70	16.50–311.58	<0.001
Both	141c	73	51.77	95.56	23.30–391.93	<0.001

^a Number of patients with POI with each characteristic.

^b Variable was included in the model as continuous.

^c Information incomplete on n = 3 patients.