Table 4.
Multivariable Cox Regression Model Fits for POI After Combining Treatment Modalities
| POI (n = 100) | ||||||
|---|---|---|---|---|---|---|
| Characteristic | N | n a | % | HR | CI | P Value | 
| Age at cancer diagnosis (years)b | ||||||
| Mean (SD) | 8.10 (5.57) | 1.02 | 0.98–1.06 | 0.41 | ||
| Oophoropexy | ||||||
| No | 863 | 80 | 9.27 | 1.00 | ||
| Yes | 58 | 20 | 34.48 | 0.72 | 0.42–1.23 | 0.23 | 
| Body mass index | ||||||
| ≥18.5–24.99 kg/m2 | 338 | 42 | 12.43 | 1.00 | ||
| <18.5 kg/m2 | 43 | 12 | 27.91 | 1.87 | 0.97–3.59 | 0.06 | 
| 25.0–29.9 kg/m2 | 224 | 29 | 12.95 | 0.92 | 0.56–1.52 | 0.74 | 
| ≥30 kg/m2 | 316 | 17 | 5.38 | 0.36 | 0.20–0.65 | 0.001 | 
| Treatment exposure | ||||||
| No alkylating agent nor ovarian radiotherapy | 318c | 2 | 0.63 | 1.00 | ||
| Alkylating agent only | 400c | 8 | 2.00 | 2.98 | 0.63–14.06 | 0.17 | 
| Ovarian radiotherapy only | 59c | 17 | 28.81 | 71.70 | 16.50–311.58 | <0.001 | 
| Both | 141c | 73 | 51.77 | 95.56 | 23.30–391.93 | <0.001 | 
Number of patients with POI with each characteristic.
Variable was included in the model as continuous.
Information incomplete on n = 3 patients.