Table 5.

Multivariable Logistic Regression Model Fits for Risk Factors for Markers of Cardiovascular Disease, Low BMD, and Frailty

Outcome Variables	POI
	Absent [N (%)]	Present [N (%)]	Unadjusted Analysis		Multivariable Analysis
			OR a	95% CI	OR a	95% CI
Increased waist circumferenceb	308 (38.64)	23 (24.73)	0.52	0.32–0.85	1.20	0.58–2.51
Increased waist-to-height ratioc	434 (52.86)	41 (41.00)	0.66	0.43–1.02	0.95	0.56–1.61
Hypertensiond	170 (21.25)	39 (40.63)	2.54	1.63–3.94	1.44	0.71–2.94
Elevated glucosee	66 (8.70)	9 (10.71)	1.26	0.60–2.63	1.38	0.64–2.99
Dyslipidemiaf	70 (8.55)	15 (15.15)	1.91	1.05–3.49	1.73	0.91–3.29
Low BMDg	17 (2.38)	10 (14.08)	6.73	2.95–15.34	5.07	1.97–13.05
Frailtyh	39 (4.89)	15 (15.96)	3.69	1.95–6.99	3.51	1.78–6.93

An unadjusted analysis was performed first to select the covariates to be included into the model (P ≤ 0.1).

^a OR is calculated for POI yes vs no.

^b Increased waist circumference: Multivariable model was adjusted for age at study, BMI ≥30 kg/m², educational attainment, and smoking status.

^c Increased waist-to-height ratio: Multivariable model was adjusted for age at study, BMI ≥30 kg/m², educational attainment, and smoking status.

^d Hypertension: Multivariable model was adjusted for age at study, age at diagnosis, ovarian radiotherapy dose (0, >0 to 999, and ≥1000 cGy), and BMI ≥30 kg/m². Significant association was found between hypertension and ovarian radiotherapy dose ≥1000 cGy (OR, 2.23; 95%CI, 1.01 to 4.92).

^e Elevated glucose: Multivariable model was adjusted for age at study and BMI ≥30 kg/m².

^f Dyslipidemia: Multivariable model was adjusted for age at study, age at diagnosis, ethnicity/race, and BMI ≥30 kg/m².

^g Low BMD: Multivariable model was adjusted for BMI ≥30 kg/m² and exposure to total body irradiation.

^h Frailty: Multivariable model was adjusted for age at diagnosis, educational attainment, current smoking status, and illicit drug use.