Table 1.
Demographic Data of the Healthy Volunteers at the Baseline Visit
|
|
Women
|
Men
|
||
|---|---|---|---|---|
| Estradiol (+) | Estradiol (−) | Testosterone (+) | Testosterone (−) | |
| Number of subjects | 8 | 4 | 9 | 7 |
| Age, y | 59 ± 3.9 | 54 ± 2.8 | 56 ± 2.2 | 58 ± 4.0 |
| BMI, kg/m2 | 25.0 ± 1.0 | 24.3 ± 1.6 | 28.4 ± 0.6 | 26.7 ± 0.7 |
| TSH, mU/L | 1.6 ± 0.4 | 3.8 ± 1.4 | 2.3 ± 0.5 | 2.5 ± 0.4 |
| Estradiol, pg/mL | 104 ± 50 | 18.2 ± 5.9 | 28.0 ± 3.4 | 28.8 ± 3.4 |
| Testosterone, ng/dL | 21.0 ± 3.3 | 12.7 ± 1.4 | 408 ± 40 | 502 ± 76 |
| Cortisol, µg/dL | 12.4 ± 1.1 | 11.5 ± 1.1 | 12.0 ± 0.8 | 13.6 ± 1.4 |
Data are shown as means ± standard error of the mean (SEM).
No statistically significant differences in basal levels between subjects randomized to receive sex steroids and those who did not receive replacement were found with the unpaired Student’s t test except for estradiol in women of the placebo group, which consisted exclusively of postmenopausal women.