. 2017 May 15;158(7):2239–2254. doi: 10.1210/en.2017-00208

Table 1.

CORT Exposure Increases Plasma CORT Levels in Both Adult and Adolescent Mice

CORT Dose	Treatment Plasma CORT (ng/mL)			Postrecovery Plasma CORT
CORT Dose	VEH	Low CORT	High CORT	VEH	Low CORT	High CORT
Adult	26.39 ± 2.57	96.36 ± 28.52	258.51 ± 115.04^a	48.06 ± 6.99	27.31 ± 1.11^b	30.29 ± 3.25^a
Adolescent	42.36 ± 9.28	40.40 ± 15.62	421.58 ± 142.60^a	26.31 ± 1.18	26.76 ± 1.63	25.13 ± 0.00

High, but not low, CORT exposure increased plasma CORT concentrations in both adult (F_{2, 16} = 3.968, P = 0.0399) and adolescent (F_{2, 16} = 10.16, P = 0.0014) mice. After recovery, plasma CORT decreased in high and low CORT adult mice (F_{2, 21} = 6.233, P = 0.0075). In adolescent mice, plasma CORT normalized to VEH levels after recovery. Post hoc Tukey tests were undertaken to probe interactions. Values are considered statistically significant at the P < 0.05 level.

^{^a}

Statistical significance between high CORT and VEH groups.

^{^b}

Statistical significance between low CORT and VEH groups (n = 4 to 8/age/treatment).