Skip to main content
. 2017 Apr 14;158(7):2086–2101. doi: 10.1210/en.2016-1821

Figure 7.

Figure 7.

Osteoblast and osteocyte death is increased in estrogen-deficient, T1D mice. (a) Ratio of RNA expression of proapoptotic marker, BAX, to the antiapoptotic marker, Bcl-2, from whole tibia. (b) Number of osteocytes per square millimeter of cortical bone in the distal femur metaphyseal region. (c) Representative images of TUNEL-stained osteocytes (×20 magnification) with arrows indicating examples of quantified osteocytes. (d) Percentage of TUNEL-stained osteocytes. (f) Percentage of TUNEL-stained osteoblasts. (e and g) Pearson correlation analyses of TUNEL-stained osteocytes and osteoblasts with TNF-α staining. Values represent the mean ± standard error (n = 10 for intact control group; n = 9 for intact T1D group; n = 12 for both OVX control and T1D group). *P < 0.05 with respect to intact control; #P < 0.05 with respect to OVX control; ^P < 0.05 with respect to T1D intact.