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. 2017 Apr 14;158(7):2086–2101. doi: 10.1210/en.2016-1821

Table 3.

Femoral and Vertebral Bone Parameters

Parameter	Control		Diabetic
Parameter	Sham (n = 10)	OVX (n = 12)	Sham (n = 9)	OVX (n = 12)
Femur trabecular
BV/TV	30.1 ± 1.7	13.4 ± 1.1^a	10.5 ± 1.5^a	4.4 ± 0.4^a^,^b^,^c
BMD (mg/mL)	297.0 ± 6.4	209.0 ± 8.1^a	186.8 ± 11.2^a	136.7 ± 6.8^a^,^b^,^c
BMC (mg)	0.43 ± 0.02	0.35 ± 0.01^a	0.32 ± 0.01^a	0.25 ± 0.02^a^,^b^,^c
Tb. Th. (µm)	56.8 ± 1.5	42.1 ± 1.0^a	38.0 ± 2.0^a	31.6 ± 1.0^a^,^b^,^c
Tb. N. (1/mm)	5.26 ± 0.21	3.17 ± 0.19^a	2.68 ± 0.24^a	1.38 ± 0.11^a^,^b^,^c
Tb. Sp. (µm)	135.8 ± 7.5	286.0 ± 19.9	358.7 ± 36.0^a	754.0 ± 74.2^a^,^b^,^c
Vertebral trabecular
BV/TV	40.2 ± 2.4	40.4 ± 2.5	28.8 ± 2.7^a^,^b	21.6 ± 1.4^a^,^b
BMD (mg/mL)	286.6 ± 9.8	284.9 ± 10.41	253.1 ± 13.3^a	200.6 ± 6.3^a^,^b^,^c
BMC (mg)	0.46 ± 0.03	0.45 ± 0.04	0.38 ± 0.03	0.37 ± 0.03
Tb. Th. (µm)	58.9 ± 2.6	56.8 ± 2.8	44.5 ± 3.0^a	37.4 ± 1.3^a^,^b
Tb. N. (1/mm)	6.79 ± 0.26	7.11 ± 0.19	6.40 ± 0.25	5.72 ± 0.23^a^,^b
Tb. Sp. (µm)	89.8 ± 6.0	84.9 ± 5.2	113.6 ± 8.5	141.3 ± 9.5^a^,^b
Femur cortical
Mean thickness (mm)	0.255 ± 0.004	0.261 ± 0.005	0.240 ± 0.006	0.229 ± 0.004^a^,^b
Inner perimeter (mm)	2.76 ± 0.03	2.76 ± 0.02	2.84 ± 0.03	2.84 ± 0.03
Outer perimeter (mm)	4.37 ± 0.03	4.40 ± 0.03	4.46 ± 0.11	4.29 ± 0.03
Marrow area (mm²)	0.54 ± 0.01	0.54 ± 0.01	0.57 ± 0.01	0.58 ± 0.02
Cortical area (mm²)	0.87 ± 0.02	0.90 ± 0.02	0.82 ± 0.02^b	0.78 ± 0.02^a^,^b
BMD (mg/mL)	1039 ± 22	1054 ± 12	983 ± 15^b	985 ± 18^a^,^b
BMC (µg)	18.2 ± 0.4	18.9 ± 0.4	16.4 ± 0.5^a^,^b	15.5 ± 0.5^a^,^b

Values represent mean ± standard error (n ≥ 5 per group).

Abbreviations: BV/TV, bone volume/total volume; Tb. N., trabecular number; Tb. Sp., trabecular spacing; Tb. Th., trabecular thickness.

^{^a}

P < 0.05 with respect to sham control.

^{^b}

P < 0.05 with respect to OVX control.

^{^c}

P < 0.05 with respect to T1D-sham.