Table 1.
Demographic and biomarker information for study participants.
| All participants | Low CSF Tau/Aβ42 | High CSF Tau/Aβ42 | Cognitively Stable | Progressors | |
|---|---|---|---|---|---|
| n= | 233 | 167 | 66 | 218 | 15 |
| Age (years)a | 60.7 ± 8.4 | 59.1 ± 8.5 | 64.9 ± 6.7**** | 60.2 ± 8.4 | 68.3 ± 5.4*** |
| Sex (% female) | 64% | 62% | 67% | 65% | 40% |
| APOE ε4 (% positive) | 36% | 27% | 61%**** | 36% | 47% |
| Family history (% positive)b | 55% | 56% | 55% | 55% | 60% |
| Education (years)a | 16.1 ± 2.5 | 16.1 ± 2.4 | 16.1 ± 2.8 | 16.1 ± 2.5 | 15.9 ± 2.9 |
| Follow-up (years)a | 5.9 ± 2.5 | 5.9 ± 2.5 | 6.0 ± 2.7 | 5.9 ± 2.5 | 6.6 ± 3.0 |
| Test interval (months)a,c | 2.9 ± 1.9 | 2.8 ± 1.9 | 3.2 ± 2.0 | 2.9 ± 1.9 | 3.4 ± 2.4 |
| CSF Aβ42 (pg/ml)a | 642 ± 226 | 706 ± 200 | 483 ± 212**** | 657 ± 222 | 437 ± 199*** |
| CSF Tau (pg/ml)a | 254 ± 122 | 206 ± 70 | 378 ± 139**** | 247 ± 116 | 369 ± 156**** |
| CSF pTau181 (pg/ml)a | 49 ± 19 | 43 ± 13 | 64 ± 24**** | 48 ± 18 | 66 ± 30*** |
| Logical memoryd | 29 ± 7 (84) | 29 ± 7 (66) | 29 ± 7 (18) | 29 ± 7 (80) | 30 ± 8 (4) |
| FCSRT - freed | 32 ± 6 (227) | 33 ± 5 (163) | 30 ± 6 (64)* | 32 ± 5 (214) | 26 ± 6 (13)*** |
| Global cognitiond | 0.0 ± 0.5 (233) | 0.1 ± 0.5 (167) | −0.1 ± 0.6 (66)* | 0.0 ± 0.5 (218) | −0.4 ± 0.7 (15)* |
| Sequencingd | 11 ± 3 (95) | 11 ± 3 (73) | 10 ± 3 (22) | 11 ± 3 (91) | 12 ± 6 (4) |
| MMSEd | 29 ± 1 (233) | 29 ± 1 (167) | 29 ± 1 (66) | 29 ± 1 (218) | 28 ± 2 (15) |
| Associate learningd | 19 ± 8 (84) | 18 ± 8 (66) | 20 ± 7 (18) | 19 ± 8 (80) | 20 ± 5 (4) |
| Trails Bd | 69 ± 27 (232) | 66 ± 25 (167) | 75 ± 31 (65)* | 67 ± 26 (218) | 99 ± 34 (14)**** |
| Trails Ad | 29 ± 10 (233) | 29 ± 10 (167) | 30 ± 10 (66) | 29 ± 10 (218) | 35 ± 8 (15)* |
| Categoryd | 23 ± 6 (232) | 23 ± 6 (167) | 22 ± 6 (65) | 23 ± 6 (218) | 22 ± 5 (14) |
Statistical comparisons are between low CSF tau/Aβ42 versus high CSF tau/Aβ42 groups or cognitively stable versus progressor groups,
*
p<0.05,
**
p<0.01,
***
p<0.001,
****
p<0.0001,
a mean ± standard deviation, b Positive family history is having 1 or more parent who developed AD dementia before age 80; negative family history is having both parents live to age 70 or greater without dementia, c Test interval is the time from baseline cognitive battery until CSF collection, d raw measure score mean ± standard deviation (n=).