Table 3. CSF biomarkers predict longitudinal cognitive performance.

Numbers listed are the linear mixed model coefficient ± standard error. Each unit indicates a one standard deviation change from the mean. A negative value indicates that a higher CSF biomarker measure is associated with declining performance over time.

	Aβ42	Tau	pTau	Tau/Aβ42	pTau/Aβ42
MMSE	0.047 ± 0.02*	−0.032 ± 0.02	−0.019 ± 0.02	−0.073 ± 0.02***	−0.064 ± 0.02***
Associate learning	0.014 ± 0.01	−0.023 ± 0.01**	−0.033 ± 0.01***	−0.028 ± 0.01**	−0.032 ± 0.01***
Global cognition	0.009 ± 0.01	−0.008 ± 0.004*	−0.008 ± 0.004*	−0.013 ± 0.004**	−0.013 ± 0.004**
FCSRT-free	0.024 ± 0.01*	−0.007 ± 0.01	−0.011 ± 0.01	−0.030 ± 0.01*	−0.035 ± 0.01**
Category	0.014 ± 0.01	−0.013 ± 0.01	−0.005 ± 0.01	−0.026 ± 0.01*	−0.019 ± 0.01
Trails B	0.023 ± 0.01*	−0.010 ± 0.01	0.000 ± 0.01	−0.024 ± 0.01*	−0.017 ± 0.1
Trails A	0.021 ± 0.01	−0.006 ± 0.01	−0.003 ± 0.01	−0.022 ± 0.01*	−0.022 ± 0.01*
Sequencing	−0.015 ± 0.02	−0.019 ± 0.02	−0.025 ± 0.02	−0.021 ± 0.02	−0.024 ± 0.02
Logical memory	−0.003 ± 0.01	−0.013 ± 0.01	−0.018 ± 0.01	−0.003 ± 0.01	−0.004 ± 0.01

Obs is the total number of observations per measure,

^*p<0.05 (yellow),

p<0.01 (orange),

p<0.001 (red)