Table 4. Temporal sequence of cognitive change.

Longitudinal cognitive performance for the high and low CSF tau/Aβ42 groups was estimated using general linear mixed models and the standardized difference on each neuropsychological measure was calculated for each time point. Each unit indicates a one standard deviation from the mean.

	Baseline	Year 1	Year 2	Year 3	Year 4	Year 5	Year 6
FCSRT-free	−0.336 ± 0.14*	−0.381 ± 0.14**	−0.427 ± 0.14**	−0.472 ± 0.15**	−0.518 ± 0.16**	−0.563 ± 0.17**	−0.608 ± 0.19**
Sequencing	−0.301 ± 0.16	−0.320 ± 0.15*	−0.339 ± 0.14*	−0.358 ± 0.14*	−0.377 ± 0.15*	−0.396 ± 0.17*	−0.415 ± 0.20*
Logical memory	−0.288 ± 0.15	−0.313 ± 0.14*	−0.339 ± 0.14*	−0.364 ± 0.14*	−0.390 ± 0.15**	−0.415 ± 0.16**	−0.441 ± 0.17**
MMSE	−0.092 ± 0.14	−0.226 ± 0.13	−0.360 ± 0.13**	−0.494 ± 0.14***	−0.628 ± 0.17***	−0.761 ± 0.20***	−0.896 ± 0.23***
Global cognition	−0.087 ± 0.07	−0.114 ± 0.07	−0.142 ± 0.07*	−0.169 ± 0.07*	−0.197 ± 0.07**	−0.224 ± 0.08**	−0.252 ± 0.08**
Trails B	−0.020 ± 0.13	−0.058 ± 0.13	−0.096 ± 0.13	−0.134 ± 0.13	−0.172 ± 0.14	−0.210 ± 0.16	−0.248 ± 0.17
Associate learning	0.165 ± 0.14	0.101 ± 0.13	0.036 ± 0.13	−0.028 ± 0.13	−0.093 ± 0.13	−0.157 ± 0.14	−0.222 ± 0.15
Category naming	0.154 ± 0.16	0.098 ± 0.15	0.042 ± 0.15	−0.014 ± 0.15	−0.071 ± 0.15	−0.127 ± 0.16	−0.183 ± 0.17
Trails A	0.093 ± 0.14	0.081 ± 0.13	0.069 ± 0.13	0.057 ± 0.13	0.045 ± 0.13	0.033 ± 0.14	0.021 ± 0.15

^*p<0.05 (yellow),

^**p<0.01,(orange),

^***p<0.001(red)