Table 5. Temporal sequence of cognitive change for cognitively stable individuals.

Longitudinal cognitive performance for the high and low CSF tau/Aβ42 groups was estimated using general linear mixed models and the standardized difference on each neuropsychological measure was calculated for each time point. Each unit indicates a one standard deviation from the mean.

	Baseline	Year 1	Year 2	Year 3	Year 4	Year 5	Year 6
FCSRT-free	−0.203 ± 0.15	−0.223 ± 0.14	−0.243 ± 0.13	−0.263 ± 0.13	−0.283 ± 0.14*	−0.303 ± 0.15*	−0.322 ± 0.16*
Sequencing	−0.316 ± 0.16	−0.307 ± 0.15*	−0.299 ± 0.14*	−0.29 ± 0.15*	−0.281 ± 0.16	−0.272 ± 0.18	−0.263 ± 0.20
Logical memory	−0.118 ± 0.15	−0.132 ± 0.14	−0.146 ± 0.14	−0.160 ± 0.14	−0.173 ± 0.14	−0.187 ± 0.15	−0.201 ± 0.16
MMSE	−0.091 ± 0.13	−0.123 ± 0.12	−0.155 ± 0.10	−0.187 ± 0.10	−0.219 ± 0.09*	−0.252 ± 0.09**	−0.284 ± 0.10**
Global cognition	−0.020 ± 0.07	−0.033 ± 0.07	−0.047 ± 0.07	−0.061 ± 0.07	−0.074 ± 0.07	−0.088 ± 0.07	−0.102 ± 0.08
Trails B	0.050 ± 0.13	0.035 ± 0.13	0.019 ± 0.13	0.004 ± 0.14	−0.012 ± 0.14	−0.027 ± 0.15	−0.043 ± 0.16
Associate learning	0.197 ± 0.15	0.158 ± 0.14	0.119 ± 0.13	0.080 ± 0.13	0.041 ± 0.13	0.002 ± 0.13	−0.037 ± 0.14
Category naming	0.151 ± 0.17	0.120 ± 0.16	0.090 ± 0.16	0.059 ± 0.16	0.029 ± 0.16	−0.002 ± 0.17	−0.032 ± 0.18
Trails A	0.078 ± 0.14	0.084 ± 0.14	0.090 ± 0.13	0.095 ± 0.13	0.101 ± 0.13	0.107 ± 0.14	0.113 ± 0.14

^*p<0.05 (yellow),

^**p<0.01 (orange)