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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Adv Pharmacol. 2014 Aug 22;71:203–243. doi: 10.1016/bs.apha.2014.06.002

Figure 3.

Figure 3

MRI and histology of the rat CNS lymphoma model. Intracerebral implantation of human MC116 B-lymphoma cells forms an infiltrative brain tumor that shows minimal leakage to gadolinium contrast on T1-weighted MRI (A). Prominent hyperintensity on T2-weighted MRI (B) correlates with tumor extent as determined by immunohistochemistry for CD20 (C). The tumor shows infiltration along fiber tracts and around blood vessels distant to the tumor mass (D and E). Panels (A)–(C) are reprinted with permission from Jahnke et al. (2009) by the permission of Society for Neuro-Oncology. Panels (D) and (E) are reprinted from Soussain et al. (2007).