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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Adv Pharmacol. 2014 Aug 22;71:203–243. doi: 10.1016/bs.apha.2014.06.002

Figure 9.

Figure 9

Long-term neuropsychological outcomes in primary CNS lymphoma survivors, according to the treatment type. Neuropsychological domain (attention/executive function, verbal memory, and motor skills) and neuropsychological composite z-score results (crude mean, SD) are shown, according to the following treatment groups: HDMTX (high-dose methotrexate) alone; HDMTX IA (intraarterial) with BBBD (blood-brain barrier disruption); HDMTX+HDT/ASCT (high-dose chemotherapy with autologous stem cell transplantation); and HDMTX+WBRT (whole brain radiotherapy) group. A z-score is the number of standard deviations above or below the mean for a population of similar age. Asterisks indicate a statistically significant difference (P<0.05) between the WBRT group and the non-WBRT groups in attention/executive function, motor skills, and composite score. Reprinted with permission from Doolittle, Korfel, et al. (2013).