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. Author manuscript; available in PMC: 2018 Jun 3.
Published in final edited form as: Neuroscience. 2017 Apr 12;352:249–261. doi: 10.1016/j.neuroscience.2017.04.002

Figure 2. A selective blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, ZD7288 (50 μM), blocked hyperpolarization activated inward currents in BF vGluT2+ neurons.

Figure 2

A. A representative neuron was stepped to -135 mV for 1s to induce an inward current (Ih) (black trace) which was blocked by ZD7288 (grey trace). The amplitude of the current was measured as the difference between the two points labeled with arrows. B. I-V plot with the voltage step values as the x-axis and Ih amplitudes shown on the y axis. Data were plotted as mean ± SEM (n=7).