Table 4. SFLCA and Light Chain Type of Primary Myeloma Protein Samples.
Primary LC | SFLCA results |
|||
---|---|---|---|---|
Concordant | Non-concordant | Discordant | ||
Kappa - 167 | 69 | 98 | 0 | Chi-square: 41.25 |
Lambda - 84 | 11 | 60 | 13 (15.5%) | P < 0.00001 |
For 251 samples with oligoclonal pattern, both the light chain type of the myeloma protein and SFLCA results were available. The results of the concordance of the SFLCA result with that of the malignant light chain revealed 13 (15.5%) cases of lambda light chain type (not just lambda light chain in isolation but any immunoglobulin with lambda light chain) exhibited kappa chain dominant κ/λ ratio. It could be surmised that of the 69 samples from patients with kappa chain myeloma protein, about 15.5% would not have exhibited kappa chain dominance of κ/λ ratio without oligoclonal pattern. Thus, the presence of oligoclonal pattern further mars the marginal usefulness of SFLCA.