TABLE 3.

Comparison of SCN Indices between various sodium and potassium channel classifications

	n	Median	25th percentile	75th percentile	Min	Max
Pathogenic/Likely Pathogenic
All SCN	440	0.985	0.965	0.992	0.046	0.999
de novo SCN	271	0.987	0.967	0.993	0.067	0.998
Inherited SCN	75	0.974	0.881	0.987	0.101	0.999
SCN1A	343	0.974	0.987	0.993	0.046	0.999
SCN2A	62	0.955	0.874	0.982	0.101	0.998
SCN8A	35	0.980	0.931	0.987	0.704	0.996
KCNQ2 and KCNQ3	68	0.971	0.938	0.987	0.004	0.997
VUS
All SCN	92	0.820	0.291	0.966	0.021	0.992
Benign
All SCN	84	0.229	0.111	0.467	0.010	0.989
KCNQ2 and KCNQ3	13	0.510	0.152	0.941	0.004	0.961
Exome Aggregate Consortium all SCN
All	911	0.299	0.123	0.751	0.002	0.997
Epilepsy	28	0.739	0.284	0.964	0.010	0.992
No Epilepsy	883	0.292	0.119	0.738	0.002	0.997
Validation SCN
Pathogenic/Likely Pathogenic	137	0.983	0.967	0.992	0.014	0.999
Benign	6	0.294	0.208	0.613	0.015	0.630