Table 4.

Stratified analysis by diabetes mellitus status using an indicator of top sex-specific quartile

	Diabetes	No Diabetes
Events/N	11/86	87/655
Mean IGF-1(SD)	152.08(66.35)	144.34(59.22)
Age and sex adjusted*	0.39 [0.20, 0.78] (0.007)	0.88 [0.69, 1.11] (0.277)
Multivariate †	0.42 [0.22, 0.79] (0.007)	0.91 [0.72, 1.16] (0.451)
Multivariate+Mediators‡	0.40 [0.20, 0.81] (0.011)	0.96 [0.77, 1.21] (0.756)

Hazard ratios, HR [95% CI], (p-values) are estimated for 1 SD (standard deviation) increase in IGF-1 levels in each category.

P-value for interaction = 0.016

HR: Hazard ratio; CI: Confidence interval; SD: Standard deviation; N: Number of observations, IS: Ischemic stroke.

^†Adjusted for age, sex, systolic blood pressure, smoking, anti-hypertensive treatment, prevalent CVD.

^‡Additionally adjusted for waist-hip ratio and atrial fibrillation.