Fig. 1.

Swimming behavior of DAT-KO vs. wildtype zebrafish. (A) The bottom dwelling in DAT-KO fish is in contrast to regular swimming pattern in genetic control wild-type (WT) zebrafish; (B) Double-plot of daily variation in swimming depth in DAT-KO vs. WT, as per % time spent in the bottom third of the tank. ZT0 (Zeitgeber time 0) = lights on time; (C) % time spent in the middle third of the tank, * p < 0.05; (D) % time spent in the top third of the tank,* p < 0.05; (E) % time spent in the bottom third of the tank for WT (white) and DAT-KO (black) animals after control, FG7142 and diazepam treatments, * p < 0.05 between control and FG7142 treatment for WT animals, # p < 0.05 between control and diazepam treatment for DAT-KO animals.