Extended Data Figure 4.

(a) UCSC Genome Browser views of ChIP-seq tracks demonstrate that increases in H4K5, H4K12, and H3K9 acetylation co-occur with ACSS2 enrichment over the Idua (Alpha-L-iduronidase) gene locus upon CAD neuron differentiation (U–undiff, D–diff; chr5: 108,649,457–108,687,261). (b) At the Slc19A1 (Solute Carrier Family 19 – Folate Transporter – Member 1) gene, elevated histone H4K5, H4K12, and H3K9 acetylation levels correspond with increasing ACSS2 enrichment in CAD neuron differentiation (chr10: 76,761,141–77,170,455).