Table 1.
Characteristics of HIV-1-infected black South African study participants classified according different clinical phenotypes of HIV-1 disease control
| Clinical Phenotype Group | n | Age (years) | Gender (%females) | CD4+ T cell counts(cells/μl)1 (Median and IQR) | Viral load(HIV RNA copies/ml)1 (Median and IQR) | logVL (Median and IQR) | Time since HIV-1 diagnosis (years) (Median and IQR) |
|---|---|---|---|---|---|---|---|
| Elite controllers (ECs) | 11 | 44 (19–54) | 81.8 | 853 (718 – 1022) | <40 (<40 (n=2), <20 (n=9)) | - | 11 9–12) |
| Viraemic controllers (VCs) | 30 | 36 (19–46) | 90.0 | 651 (555–832)2 | 495 (327 - 965)3 | 2.69 (2.51–2.98) | 3 (0–10.35) |
| High viral load long term nonprogressors (HVL LTNPs) | 11 | 41 (31–51) | 81.8 | 663 (635–749) | 54 375 (13 415–77 820) | 4.74 (4.12–4.89) | 8 (8–11) |
| Progressors | 72 | 38 (24–66) | 83.3 | 177 (146–210) | 38 444 (19–853–103 042) | 4.58 (4.30–5.01) | 6 (1–7) |
1
CD4+ T cell counts and viral loads of controllers used were from time of enrolment whereas for the progressors the last CD4+ T cell count and viral load prior to ART initiation was used.
2
Three individuals had CD4+ T cell counts <500 cells/μl at time of enrolment; however were included based on length of time of infection since diagnosis to time of enrolment, in the absence of ART (≥9 years).
3
One individual had a VL>2 000 (VL=6070), but was classified as a VC also due to length of infection since diagnosis with viral control in the absence of ART (9 years).