Table 3.

Comparison of CXCR6 single nucleotide polymorphism, rs2234355 and rs2234358, prevalence between populations investigated in this study and other populations of similar ancestry

	Populations with sub-Saharan African ancestry					Populations with European ancestry
	Black South Africans (n)	Nigeria- Yoruba (n)a	Black SAs vs.Yorouba P	Kenya- Luhya (n) a	Black SAs vs.Luhya P	Caucasian South Africans (n)	Caucasians (Utah) (n) a	Caucasian SAs vs. Utah P	Tuscans in Italy (n) a	Caucasian SAs vs. Tuscans P
CXCR6 SNP rs2234358 (3 UTR)
Allele
G	0.409 (190)	0.245 (53)	<0.001	0.364 (72)	0.298	0.513 (41)	0.510 (101)	1	0.565 (121)	0.432
T	0.591 (274)	0.755 (163)		0.636 (126)		0.488 (39)	0.490 (97)		0.435 (93)
Genotype
GG	0.164 (38)	0.037 (4)	0.001	0.141 (14)	0.627	0.300 (12)	0.263 (26)	0.678	0.355 (38)	0.564
GT	0.491 (114)	0.417 (45)	0.202	0.444 (44)	0.471	0.425 (17)	0.495 (49)	0.574	0.421 (45)	1
TT	0.345 (80)	0.546 (59)	<0.001	0.414 (41)	0.262	0.275 (11)	0.242 (24)	0.829	0.224 (24)	0.664
CXCR6 SNP rs2234355 (3EK)
Allele
G	0.517 (242)	0.398 (86)	0.004	0.581 (115)	0.149	0.988 (79)	1.000 (198)	0.288	0.991 (212)	1
A	0.483 (226)	0.602 (130)		0.419 (83)		0.013 (1)	0		0.009 (2)
Genotype
GG	0.265 (62)	0.148 (16)	0.018	0.354 (35)	0.114	0.975 (39)	1.000 (99)	0.288	0.981 (105)	1
GA	0.504 (118)	0.500 (54)	1	0.455 (45)	0.472	0.025 (1)	0	0.288	0.019 (2)	1
AA	0.231 (54)	0.352 (38)	0.025	0.192 (19)	0.471	0	0	1	0	1

^aData from the 1000 Genomes project [20]

SAs: South Africans

Grey shading indicates significant difference (P <0.05) between South African healthy population SNP frequency and reference population