Table 1. Astragalus polysaccharides (APS) rescued cardiac dysfunction in diabetic mice at 24 weeks.
| Ctrl | DM | DM-APS | SOD2+/- | APS-SOD2+/- | DM-SOD2+/- | APS-DM-SOD2+/- | |
|---|---|---|---|---|---|---|---|
| Heart rate (bpm) | 506±16 | 516±14 | 502±12 | 520±16 | 508±11 | 522±12 | 500±13 |
| LV systolic pressure (mmHg) | 98.1±2.1 | 82.5±3.0+ | 97.2±2.2* | 83.6±2.3+ | 98.6±1.8# | 81.5±3.6+ | 96.8±1.2& |
| LVPW (mm) | 1.11±0.06 | 1.42±0.03+ | 1.11±0.08* | 1.44±0.07+ | 1.12±0.06# | 1.45±0.08+ | 1.11±0.03& |
| IVS (mm) | 0.70±0.01 | 0.84±0.04+ | 0.72±0.03* | 0.85±0.06+ | 0.72±0.02# | 0.86±0.07+ | 0.73±0.02& |
| LVID (mm) | 3.2±0.02 | 3.6±0.04+ | 3.3±0.03* | 3.7±0.03+ | 3.3±0.03# | 3.8±0.08+ | 3.3±0.04& |
| LVFS (%) | 60±2.8 | 36±1.4+ | 56±2.4* | 34±1.3+ | 55±2.3# | 32±1.0+ | 52±2.0& |
| LV end diastolic pressure (mmHg) | 7.6±1.2 | 11.8±3.2+ | 7.8±1.6* | 12.1±2.4+ | 7.3±1.0# | 12.2±1.8+ | 7.4±0.9& |
| LV dP/dtmax (mmHg/s) | 8342±477 | 5110±602+ | 8258±352* | 5225±424+ | 8224±245# | 5028±612+ | 8210±312& |
| LV dP/dtmin (-mmHg/s) | 6840±573 | 4442±325+ | 6702±477* | 4612±288+ | 6460±498# | 4218±250+ | 6512±388& |
Data are reported as means±SE. DM: diabetic mice; DM-SOD2+/-: diabetic SOD2+/- mice; APS-DM-SOD2+/-: diabetic SOD2+/- mice with APS treatment; APS-DM: diabetic mice with APS treatment (n=20 per group); LV: left ventricle; LVPW: left ventricular posterior wall thickness; IVS: inter-ventricular septal wall thickness; LVID: left ventricular internal diameter; LVFS: left ventricular fractional shortening.
*
P<0.05 vs diabetic mice;
#
P<0.05 vs SOD2+/-mice;
&
P<0.05 vs diabetic SOD2+/- mice;
+
P<0.05 vs C57BJ/6J control mice.