Table 4.
Summary of three studies assessing reproductive outcome with IVF or ICSI after polyp removal or expectant management.
Study | Design | Patients | Intervention | Pregnancy Rate | Spontaneous Miscarriage Rate | Ongoing Pregnancy Rate | |||
---|---|---|---|---|---|---|---|---|---|
S | C | S | C | S | C | ||||
Lass et al. | RCC | 70 subfertile women age 35.4±3.6 (S) 35.4±3.8 (C) EP <20 mm |
HSC polypectomy + IVF + FET vs. IVF | 7/21 | 11/49 | 1/7 | 3/11 | 28.6% 6/21 |
16.3% 8/49 |
Isikoglu et al. | RCC | 55 subfertile women age 28-34 (S) 29-38 (C) majority of EP <15 mm |
HSC polypectomy + ICSI vs. ICSI | 18/40 | 8/15 | 0/18 | 1/8 | 45.0% 18/40 |
46.7% 7/15 |
Ghaffari et al. | CS | 86 subfertile women age 33.9±3.9 (S) 32.5±4.4 (C) matched by polyp size, EP <20mm |
HSC polypectomy + ICSI vs. ICSI | 15/43 | 14/43 | 2/15 | 2/14 | 30.2% 13/43 |
27.9% 12/43 |
Average | 40/104 | 33/107 | 3/40 | 6/33 |
35.6% 37/104 |
25.2% 27/107 |
S=Study Group, C=Control Group
RCC=retrospective case control
CS=cross-sectional
EP=endometrial polyp
HSC=hysteroscopic
IVF=in vitro fertilization
FET=frozen embryo transfer
ICSI=intracytoplasmic sperm injection