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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Chembiochem. 2017 Jan 20;18(4):413–423. doi: 10.1002/cbic.201600516

Figure 1.

Figure 1

Schematic representation of the agr QS circuit in S. aureus. A) a: The agr operon is expressed to produce the Agr proteins A–D. b and c: The AIP precursor AgrD is processed by AgrB and the mature AIP is transported out of the cell. d: The AIP signal binds to and activates AgrC, a transmembrane receptor and preformed dimer. e: AgrC phosphorylates and activates AgrA, the response regulator. f: AgrA binds promoters P2 and P3 and initiates transcription. See text. B) Structures of the four known S. aureus AIPs (I–IV). Single letter abbreviations used for amino acid residues.