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. 2017 Jul 4;10:3289–3297. doi: 10.2147/OTT.S138123

Figure 6.

Figure 6

Overview of the hypothesized mechanism of sinuleptolide-induced killing of human oral cancer cells (Ca9-22) involving oxidative stress.

Notes: The role of oxidative stress was demonstrated by pretreatment with NAC that scavenges ROS and prevents mitochondrial superoxide generation. NAC consequently inhibits DNA damage and cell death.

Abbreviations: NAC, N-acetylcysteine; ROS, reactive oxygen species.