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. 2016 Jul 28;1:16002. doi: 10.1038/npjvaccines.2016.2

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Protective vaccination is associated with reduced Nipah virus pathogenesis. Lung sections from four hamsters per group were collected 5 days after challenge and stained with H&E for histology. (a–f) Taken from representative, unprotected DMEM control animals and show moderate-to-marked interstitial pneumonia with necrosis and inflammation (arrows), and alveolar oedema and fibrin (asterisk). (g–l) Derived from rVSV-EBOV-GP-NiV-G animals. (g) An example of normal tissue from a protected animal. (h, i) Minimal interstitial pneumonia with rare foci of alveolar interstitial inflammation (arrow). (j) Mild interstitial pneumonia with larger more frequent areas of inflammation (arrows). (k, l) Animals with moderate-to-marked interstitial pneumonia with coalescing inflammation in k, and necrosis, inflammation and alveolar oedema, and fibrin (asterisk) in l.