Table 1.
Baseline characteristics of the 420 volunteers randomized to metformin/placebo within the whole population enrolled in MeMeMe trial8
| Characteristic | Placebo (207) (mean ± SD) | Metformin (213) (mean ± SD) | P-value* |
|---|---|---|---|
| Age (years) | 63.32±3.68 | 64.29±5.13 | 0.10 |
| Sex (n, %) | Male (75, 36%) | Male (71, 33%) | |
| Female (132, 64%) | Female (142, 67%) | ||
| Weight (kg) | 87.25±16.98 | 84.39±14.76 | 0.094 |
| Waist circumference (cm) | 100.04±12.29 | 98.74±10.79 | 0.29 |
| Diastolic pressure (mmHg) | 88.77±9.39 | 89.42±9.08 | 0.51 |
| Systolic pressure (mmHg) | 144.57±16.1 | 150.18±34.7 | 0.053 |
| Glycemia (mg/dL) | 103.58±10.21 | 103.59±10.0 | 0.99 |
| Total cholesterol (mg/dL) | 215.44±36.80 | 215.94±38.56 | 0.90 |
| HDL (mg/dL) | 52.87±13.13 | 58.13±15.09 | <0.01 |
| LDL (mg/dL) | 135.36±33.11 | 133.43±35.2 | 0.60 |
| Triglycerides (mg/dL) | 135.94±62.11 | 131.18±55.67 | 0.08 |
| AST (IU/L) | 22.16±18.20 | 20.61±6.50 | 0.29 |
| ALT (IU/L) | 26.12±13.27 | 23.12±10.53 | 0.02 |
| GammaGT (IU/L) | 33.11±25.37 | 31.24±20.67 | 0.45 |
| Education (n, %) | |||
| Junior high school | (46, 22%) | (49, 23%) | 0.20 |
| High school | (120, 58%) | (132, 62%) | |
| University | (41, 20%) | (32, 15%) | |
| Working/retired (n, %) | |||
| Working | (139, 67%) | (149, 70%) | 0.98 |
| Retired | (68, 33%) | (64, 30%) | |
Notes:
*
Student’s t-test P-value for continuous variables, chi-squared test P-value for qualitative variables. Statistically significant values are shown in bold.
Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.