. 2017 Apr 13;102(2):253–263. doi: 10.1189/jlb.1MR1016-434RR

TABLE 1.

Phenotypes of stem/progenitor populations that may contribute to development of adult LEC lineage

Population or cell type		Species	Typical phenotype-defining markers	Reference (example)
Full name	Short name	Species	Typical phenotype-defining markers	Reference (example)
Adult lymphatic endothelial cell	LEC	Mouse or human	VEGFR-3, LYVE-1, PDPN, PROX-1	[95]
Hematopoietic stem cell	HSC	Mouse	CD34⁺, c-Kit⁺, Sca-1⁺	[45]
Hematopoietic stem cell	HSC	Human	CD34⁺, CD133⁺	[52]
Common myeloid progenitor	CMP	Mouse	Lin⁻, Sca-1⁺, IL-7Rα⁻, c-Kit⁺	[48]
Mesenchymal stem cell	MSC	Mouse	Sca-1⁺, CD34⁻, CD45⁻, CD11b⁻,	[96]
Mesenchymal stem cell	MSC	Human	CD73⁺, CD105⁺, CD90⁺, CD14⁻, CD31⁻, CD34⁻, CD45⁻	[97]
Adult adipose-derived stem cell	ADSC	Human	CD13⁺, CD29⁺, CD44⁺, CD105⁺	[47]
Adult adipose-derived stem cell	ADSC	Human	CD31⁻, CD34⁻, CD45⁻, HLA-DR⁻	[47]
Endothelial progenitor cell	EPC	Human	CD34⁺, CD133⁺, VEGFR-2⁺	[98, 99]
Lymphatic endothelial cell progenitor or lymphatic endothelial precursor cell	LECP or LEPC	Human	CD34⁺, CD133⁺, VEGFR-3⁺	[57, 76]
Myeloid-derived lymphatic endothelial cell progenitor	M-LECP	Human	Combined markers for early progenitors (CD133, CD34), myeloid cells (CD14, CD11b), and adult LECs (VEGFR-3, PDPN, LYVE-1)	[57]
Myeloid-derived lymphatic endothelial cell progenitor	M-LECP	Mouse	Combined markers for myeloid cells (CD11b, F4/80) and adult LECs (Vegfr-3, Pdpn, Lyve-1)	[23]

PROX-1, Prospero homeobox 1.