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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Microcirculation. 2017 Jul;24(5):10.1111/micc.12357. doi: 10.1111/micc.12357

Figure 1.

Figure 1

Schematic of the microfluidic device. (A) Photograph of microfluidic device with 3D illustration depicting the oxygen gas channel and blood microchannel layers. The device comprises multiple PDMS layers that are bonded using oxygen plasma activation. This multi-layered approach allows for the precise control of oxygen gas tension in the blood microchannel layer. (B) Cross-section view of the device showing the three layers of the device (illustration is not to scale). (C) Top down view of the microvascular portion of device with illustrated oxygen channels above. Gas with varying oxygen tension are perfused through each of the oxygen gas channels (B,C) to generate linear oxygen gradients in the microvascular layer.