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. Effects of simvastatin topical application on hypertrophic scar formation. There is a dose response with low-, medium-, and high-dose simvastatin on scar reduction. Coapplication of high-dose simvastatin with cholesterol also significantly reduced hypertrophic scarring compared with controls as shown by improvements in SEI. hsim/c, High-dose simvastatin with cholesterol; lsim, msim, hsim, low-, medium-, and high-dose simvastatin; N.S., not significant; veh, vehicle; ***P < 0.005.
