Table 1.

Characteristics of all patients enrolled in this study.

Characteristics	Response		p	Overall toxicity		p	Hematological toxicity		p	Gastrointestinal toxicity		p
	Responders	Non-responders		Low toxicity	High toxicity		Low toxicity	High toxicity		Low toxicity	High toxicity
Total	262	847		886	392		981	291		1127	151
Gender			0.308			0.011			0.147			0.074
Male	195	603		660	265		720	201		836	89
Female	67	244		226	127		261	90		291	62
Age(years)			0.166			0.891			0.378			0.060
<60	142	500		523	233		588	166		656	100
≥60	120	347		363	159		393	125		471	51
Smoke condition			0.488			0.287			0.566			0.051
Smoker	142	500		366	175		411	128		466	75
Non-smoker	120	347		520	217		570	163		661	76
Histology			0.051			0.039			0.002			0.236
Adenocarcinoma	89	247		307	112		344	73		363	56
Squamous cell	132	498		478	231		524	181		631	78
Other	41	102		101	49		113	37		133	17
Pathological stage			0.087			0.268			0.232			0.402
III	79	222		249	102		275	75		314	37
IV	155	572		563	269		623	204		730	102
Other	28	53		74	21		83	12		83	12
PS
1	144	582	0.000	530	206	0.032	567	164	0.468	671	65	0.001
2	103	247		309	158		353	113		398	69
Other	15	18		47	28		61	14		58	17