Table 2.
Multi-dimensional gene-gene interaction in discovery stage and validation stage.
| Study Component | Phenotype | Model | Training Bal. Acc. | Testing Bal. Acc. | Sign Test (p) | CV Consistency |
|---|---|---|---|---|---|---|
| Discovery | Overall toxicity | |||||
| rs2231142-rs228589-rs2929970 | 0.666 | 0.473 | 4 (0.828) | 2/10 | ||
| rs2228528-rs462779-rs2929970-rs189037 | 0.740 | 0.487 | 4 (0.828) | 3/10 | ||
| rs3776332-rs2228528-rs462779-rs2977549-rs189037 | 0.816 | 0.493 | 5 (0.623) | 5/10 | ||
| rs3776332-rs799917-rs2228528-rs462779-rs2977549-rs189037 | 0.885 | 0.565 | 6 (0.377) | 4/10 | ||
| Hematologic toxicity | ||||||
| rs799917-rs28688207-rs2977530 | 0.688 | 0.538 | 6 (0.377) | 6/10 | ||
| rs2231142-rs3859104-rs228589-rs2977549 | 0.761 | 0.517 | 4 (0.828) | 2/10 | ||
| rs799917-rs2228528-rs462779-rs4658-rs189037 | 0.841 | 0.527 | 7 (0.172) | 4/10 | ||
| rs3776332-rs799917-rs2228528-rs228589-rs462779-rs4658 | 0.906 | 0.533 | 5 (0.623) | 5/10 | ||
| Gastrointestinal toxicity | ||||||
| rs462779-rs2929970-rs189037 | 0.716 | 0.542 | 6 (0.377) | 5/10 | ||
| rs3776332-rs2070804-rs462779-rs189037 | 0.796 | 0.554 | 9 (0.012) | 5/10 | ||
| rs3776332-rs799917-rs2228528-rs2977549-rs189037 | 0.877 | 0.612 | 10 (0.001) | 9/10 | ||
| rs3776332-rs799917-rs2228528-rs4658-rs2977549-rs189037 | 0.922 | 0.593 | 7 (0.172) | 5/10 | ||
| Sensitivity | ||||||
| rs2228528-rs28688207-rs2977530 | 0.719 | 0.547 | 8 (0.055) | 4/10 | ||
| rs3776332-rs2228528-rs4658-rs2977549 | 0.801 | 0.501 | 5 (0.623) | 3/10 | ||
| rs3776332-rs2228528-rs228589-rs462779-rs2977549 | 0.877 | 0.516 | 5 (0.623) | 2/10 | ||
| rs3776332-rs799917-rs2228528-rs228589-rs462779-rs4658 | 0.933 | 0.547 | 9 (0.011) | 4/10 | ||
| Validation | Gastrointestinal toxicity | |||||
| rs3776332-rs2070804-rs462779-rs189037 | 0.749 | 0.434 | 2 (0.989) | 10/10 | ||
| rs3776332-rs799917-rs2228528-rs2977549-rs189037 | 0.706 | 0.504 | 6 (0.377) | 10/10 | ||
| Sensitivity | ||||||
| rs2228528-rs28688207-rs2977530 | 0.530 | 0.471 | 4 (0.828) | 10/10 | ||
| rs3776332-rs799917-rs2228528-rs228589-rs462779-rs4658 | 0.810 | 0.448 | 2 (0.989) | 10/10 | ||