Table 3.
Multi-dimensional gene-environment interaction in discovery stage.
| Phenotype | Model | Training Bal. Acc. | Testing Bal. Acc. | Sign Test (p) | CV Consistency |
|---|---|---|---|---|---|
| Overall toxicity | |||||
| rs228589-rs2929970 | 0.616 | 0.529 | 7 (0.172) | 3/10 | |
| rs2228528-rs2929970-Histology | 0.672 | 0.542 | 9 (0.011) | 3/10 | |
| rs2228528-rs462779-rs2929970-Histology | 0.745 | 0.546 | 8 (0.055) | 6/10 | |
| rs2228528-rs462779-rs2929970-rs189037-Histology | 0.824 | 0.559 | 8 (0.055) | 7/10 | |
| rs3776332-rs799917-rs2228528-rs2977549-rs189037-Histology | 0.894 | 0.561 | 9 (0.011) | 8/10 | |
| Hematologic toxicity | |||||
| rs2231142-rs2070804 | 0.626 | 0.499 | 4 (0.828) | 4/10 | |
| rs799917-rs28688207-rs2977530 | 0.689 | 0.520 | 6 (0.377) | 5/10 | |
| rs2228528-rs462779-rs4658-Histology | 0.762 | 0.475 | 1 (0.999) | 2/10 | |
| rs799917-rs2228528-rs462779-rs4658-rs189037 | 0.844 | 0.521 | 6 (0.377) | 2/10 | |
| rs3776332-rs2228528-rs228589-rs462779-rs2977549-Histology | 0.914 | 0.473 | 3 (0.945) | 3/10 | |
| Gastrointestinal toxicity | |||||
| rs2977549-PS | 0.649 | 0.532 | 6 (0.377) | 4/10 | |
| rs462779-rs2929970-rs189037 | 0.717 | 0.513 | 5 (0.623) | 4/10 | |
| rs3776332-rs2070804-rs462779-rs189037 | 0.798 | 0.525 | 8 (0.055) | 3/10 | |
| rs3776332-rs799917-rs2228528-rs2977549-rs189037 | 0.877 | 0.612 | 10 (0.001) | 9/10 | |
| rs3776332-rs799917-rs2228528-rs2977549-rs189037-Histology | 0.927 | 0.496 | 4 (0.828) | 3/10 | |
| Sensitivity | |||||
| rs2228528-Histology | 0.661 | 0.550 | 8 (0.055) | 6/10 | |
| rs3776332-rs4658-Histology | 0.720 | 0.539 | 8 (0.055) | 3/10 | |
| rs3776332-rs2228528-rs4658-Histology | 0.808 | 0.636 | 10 (0.001) | 7/10 | |
| rs3776332-rs2228528-rs228589-rs2977549-Histology | 0.889 | 0.674 | 10 (0.001) | 7/10 | |
| rs3776332-rs2228528-rs228589-rs462779-rs2977549-Histology | 0.941 | 0.605 | 8 (0.055) | 4/10 | |