Table 4.
Multi-dimensional gene-environment interaction in validation stage.
| Phenotype | Model | Training Bal. Acc. | Testing Bal. Acc. | Sign Test (p) | CV Consistency |
|---|---|---|---|---|---|
| Overall toxicity | |||||
| rs2228528-rs2929970-Histology | 0.564 | 0.536 | 8 (0.055) | 10/10 | |
| rs2228528-rs462779-rs2929970-Histology | 0.582 | 0.473 | 4 (0.828) | 10/10 | |
| rs2228528-rs462779-rs2929970-rs189037-Histology | 0.649 | 0.495 | 6 (0.377) | 10/10 | |
| rs3776332-rs799917-rs2228528-rs2977549-rs189037-Histology | 0.717 | 0.495 | 5 (0.623) | 10/10 | |
| Gastrointestinal toxicity | |||||
| rs3776332-rs2070804-rs462779-rs189037 | 0.749 | 0.434 | 2 (0.989) | 10/10 | |
| rs3776332-rs799917-rs2228528-rs2977549-rs189037 | 0.706 | 0.504 | 6 (0.377) | 10/10 | |
| Sensitivity | |||||
| rs4658-rs3776332-rs2228528-Histology | 0.665 | 0.591 | 9 (0.011) | 10/10 | |
| rs3776332-rs2228528-rs228589-rs2977549-Histology | 0.685 | 0.562 | 8 (0.055) | 10/10 | |
| rs3776332-rs2228528-rs228589-rs2977549-rs462779-Histology | 0.760 | 0.500 | 4 (0.828) | 10/10 | |