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. 2017 Jul 11;7:5067. doi: 10.1038/s41598-017-05314-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inh2-B1 disrupts the formation S. aureus biofilms. (A) Biofilms formation by S. aureus MW2 wild-type, MW2ΔSTK1 and MW2ΔSTP1 mutant strains in the absence and presence of 25 µM Inh2-B1 after 48 h. (B) Effect of Inh2-B1 (25 µM) on the preformed biofilms by S. aureus MW2 wild-type, MW2ΔSTK1, and MW2ΔSTP1 mutant strains. Biofilm formation was quantitatively estimated after 48 h of incubation by the crystal violet staining method. Bar diagrams represent average values (Mean ± S.D) obtained for different parameters from three independent cultures each with three technical replicates. P < 0.05 was treated as a significant difference.