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. 2017 Jul 11;7:5070. doi: 10.1038/s41598-017-05336-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The 2B7/MW1 conformational immunoassay detects mHTT conformation in homogenates of control and HD post-mortem human brains (cortex). (A) Table illustrating the salient features of human control and HD donors of samples for this study. (B) Summary of 2B7/MW1 conformational immunoassay data (ratio TR-FRET signals at 4 °C/20 °C) obtained on homogenates of control and HD brain samples. (C) Summary of 2B7/4C9 control immunoassay data (ratio TR-FRET signals at 4 °C/20 °C) obtained on the same homogenates of control and HD brain samples. (D) Same as A, plotted against CAG (polyQ) repeat length rather than against control/HD genotype. In B and C values represent means and standard deviations of the means of three independent experiments (Datasets were tested for normality and Student’s t-test, degrees of significance are indicated). Signals obtained from TR-FRET immunoassays, preparatory for the conformational analysis, are reported in Supplementary Information: Figure S6.