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. 2017 Jul 11;7:5121. doi: 10.1038/s41598-017-04974-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The activity of the human TPC1 channel is inhibited by naringenin. (a) Currents (lower panel) recorded in control conditions (trace 4) or adding in the cytosolic bath solution: 90 nM PI(3,5)P₂ (trace 1), 90 nM PI(3,5)P₂ and 500 μM Nar (trace 2), 500 μM Nar (trace 3). In the upper panel the voltage profile is shown. (b) Percentage of current inhibition induced by 500 μM Nar added in the cytosolic solution at −40 and + 40 mV. Data from 6 different vacuoles, shown as mean ± s.e.m., were not statistically significant (P > 0.6).