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. 2017 Jul 11;7:5121. doi: 10.1038/s41598-017-04974-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Naringenin impairs VEGF-induced vessel formation in vitro. (a) Representative images of one of three independent experiments. HUVECs were plated in Matrigel-coated dishes and incubated for 3–4 h in EBM-2 + 2% FBS supplemented or not with VEGF or Nar, or in medium containing both VEGF and Nar. (c) Representative images of one of three independent experiments. HUVECs were plated in Matrigel-coated dishes and incubated for 2–3 h in EGM-2 supplemented or not with Ang-1 or Nar, or in medium containing both Ang-1 and Nar. (b,d) Quantitative evaluation of tube formation as the number of closed polygons formed in 6 fields for each experimental condition for VEGF (b) and Ang-1 (d). Data in bar charts represent mean ± s.e.m. of three independent experiments. *P < 0.05.