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. 2017 Jul 11;7:5160. doi: 10.1038/s41598-017-04896-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Design of the experimental plan. C57Bl/6 and DBA/2 mice were all individually housed at 13 weeks and calorie restriction was started in the calorie restricted (CR) group at 14 weeks of age. 10% calorie restriction was applied the first week, 25% calorie restriction the week after (mice aged 15 weeks) and 40% calorie restriction was started from 16 weeks of age until the end of the experiments. Control mice were fed ad libitum for all the length of the experiment. In the injury cohort, mice had their right tibialis anterior (TA) injected with notexin and experiments were terminated one week later, when mice reached the age of 6, 12 or 22 months (after 2.5, 8.5 or 18.5 months CR).