Table 3.
Stromal Cells (% of total live, mononucleated cells).
| Control | CR | |||||
|---|---|---|---|---|---|---|
| Mean | ± SEM | n | Mean | ± SEM | n | |
| Stromal Cells (% of total live, mononucleated cells) | ||||||
| 6 months | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 5.1* | 0.4* | 7* | 3.0* | 0.2* | 7* |
| DBA/2 | 4.9 | 1.3 | 6 | 4.3 | 1.6 | 5 |
| Males | ||||||
| C57BL/6 | 4.5 | 0.6 | 4 | 2.9 | 0.4 | 4 |
| DBA/2 | 5.0 | 0.1 | 2 | 4.2 | 0.7 | 2 |
| Females | ||||||
| C57BL/6 | 5.8 | 0.2 | 3 | 3.0 | 0.3 | 3 |
| DBA/2 | 4.9 | 0.8 | 4 | 4.4 | 1.3 | 3 |
| 12 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 4.3 | 0.5 | 9 | 3.6 | 0.2 | 8 |
| Males | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 4.4 | 0.8 | 5 | 3.6 | 0.3 | 4 |
| Females | ||||||
| C57BL/6 | 2.8& | 1.2& | 3& | 2.6 | 0.9 | 3 |
| DBA/2 | 4.3& | 0.4& | 4& | 3.6 | 0.3 | 4 |
| 22 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 6.3~ # | 0.4~ # | 10~ # | 4.4~ | 0.6~ | 7~ |
| DBA/2 | 8.0# o | 0.6# o | 6# o | 5.5o | 0.8o | 7o |
| Males | ||||||
| C57BL/6 | 6.3^ | 0.6^ | 7^ | 4.4^ | 1.0^ | 4^ |
| DBA/2 | 7.9 | 0.8 | 4 | 6.4 | 0.9 | 3 |
| Females | ||||||
| C57BL/6 | 6.4 | 0.8 | 3 | 4.3 | 1.0 | 3 |
| DBA/2 | 8.3 | 1.9 | 2 | 4.8 | 1.2 | 4 |
| Macrophages (% of total live, mononucleated cells) | ||||||
| 6 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 0.42* | 0.17* | 7* | 0.28 | 0.08 | 7 |
| DBA/2 | 1.5 * | 0.6 * | 4 * | 0.58 | 0.3 | 5 |
| Males | ||||||
| C57BL/6 | 0.61 | 0.3 | 4 | 0.35 | 0.1 | 4 |
| DBA/2 | — | — | — | 0.20 | 0.02 | 3 |
| Females | ||||||
| C57BL/6 | 0.17& | 0.06& | 3& | 0.18 | 0.13 | 3 |
| DBA/2 | 2.0& | 0.46& | 3& | 1.0 | 0.9 | 2 |
| 12 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 0.41 | 0.2 | 9 | 0.20 | 0.04 | 7 |
| Males | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 0.21 | 0.04 | 5 | 0.17 | 0.02 | 3 |
| Females | ||||||
| C57BL/6 | 8.3~ # | 2.1~ # | 3~ # | 4.6~ ^ | 0.4~ ^ | 3~ ^ |
| DBA/2 | 0.66# | 0.4# | 4# | 0.22^ | 0.7^ | 4^ |
| 22 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 2.1 | 0.3 | 9 | 1.3 | 0.4 | 6 |
| DBA/2 | 2.8+ | 0.5+ | 6+ | 1.1+ | 0.2+ | 7+ |
| Males | ||||||
| C57BL/6 | 2.2∞ | 0.5∞ | 6∞ | 0.9∞ | 0.3∞ | 3∞ |
| DBA/2 | 2.5w | 0.4w | 4w | 1.1w | 0.2w | 3w |
| Females | ||||||
| C57BL/6 | 1.9 | 0.2 | 3 | 1.6 | 0.6 | 3 |
| DBA/2 | 3.3 | 1.9 | 2 | 1.2 | 0.3 | 4 |
| HSCs (% of total live, mononucleated cells) | ||||||
| 6 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 1.6* | 0.2* | 6* | 0.52 * | 0.06 * | 6 * |
| DBA/2 | 1.1 | 0.2 | 5 | 1.3 | 0.4 | 4 |
| Males | ||||||
| C57BL/6 | 1.4& | 0.1& | 4& | 0.55& | 0.1& | 4& |
| DBA/2 | 1.3 | 0.1 | 2 | 0.8 | 0.1 | 2 |
| Females | ||||||
| C57BL/6 | 1.9 | 0.7 | 2 | 0.45 | 0.1 | 2 |
| DBA/2 | 1.0 | 0.3 | 3 | 2.2 | 1.0 | 2 |
| 12 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 2.3~ | 0.6~ | 8~ | 0.59~ | 0.1~ | 7~ |
| Males | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 1.0#° | 0.1#° | 4#° | 0.58° | 0.01° | 3° |
| Females | ||||||
| C57BL/6 | 4.4^ | 2.0^ | 3^ | 0.93^ | 0.8^ | 3^ |
| DBA/2 | 2.8#+ | 0.7#+ | 4#+ | 0.60+ | 0.2+ | 4+ |
| 22 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 2.8∞¥ | 0.4∞¥ | 9∞¥ | 1.0∞ | 0.3∞ | 6∞ |
| DBA/2 | 5.3¥° | 0.8¥° | 6¥° | 2.3° | 0.5° | 7° |
| Males | ||||||
| C57BL/6 | 2.5¶ | 0.3¶ | 6¶ | 1.1 | 0.5 | 3 |
| DBA/2 | 5.4¶ ≠ | 1.1¶≠ | 4¶ ≠ | 2.7≠ | 1.3≠ | 3≠ |
| Females | ||||||
| C57BL/6 | 3.4” | 1.0” | 3” | 1.0” | 0.2” | 3” |
| DBA/2 | 5.3 | 2.2 | 2 | 1.9 | 0.3 | 4 |
| FAPs (% of total live, mononucleated cells) | ||||||
| 6 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 4.4* | 0.3* | 7* | 2.4* | 0.2* | 7* |
| DBA/2 | 3.5 | 0.6 | 6 | 2.7 | 0.5 | 5 |
| Males | ||||||
| C57BL/6 | 4.1 | 0.5 | 4 | 2.4 | 0.4 | 4 |
| DBA/2 | 4.7 | 0.4 | 2 | 3.5 | 0.3 | 2 |
| Females | ||||||
| C57BL/6 | 5.1& ~ | 0.1& ~ | 3& ~ | 2.4& | 0.3& | 3& |
| DBA/2 | 2.9~ | 0.8~ | 4~ | 2.1 | 0.8 | 3 |
| 12 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 3.9 | 0.4 | 9 | 3.1 | 0.2 | 8 |
| Males | ||||||
| C57BL/6 | — | — | — | — | — | — |
| DBA/2 | 3.9 | 0.6 | 5 | 2.9 | 0.2 | 4 |
| Females | ||||||
| C57BL/6 | 2.4+ | 0.9+ | 3+ | 1.9∞ | 0.6∞ | 3∞ |
| DBA/2 | 3.9+ | 0.3+ | 4+ | 3.2∞ | 0.3∞ | 4∞ |
| 22 month | ||||||
| Pooled sexes | ||||||
| C57BL/6 | 5.1¥ | 0.5¥ | 10¥ | 2.5¥° | 0.2¥° | 7¥° |
| DBA/2 | 6.0¶ | 0.8¶ | 6¶ | 4.2°¶ | 0.6°¶ | 7°¶ |
| Males | ||||||
| C57BL/6 | 5.1≠ | 0.7≠ | 7≠ | 2.5≠° | 0.2≠° | 4≠° |
| DBA/2 | 5.4 | 0.9 | 4 | 4.7° | 0.6° | 3° |
| Females | ||||||
| C57BL/6 | 5.0= | 0.9= | 3= | 2.6= | 0.3= | 3= |
| DBA/2 | 7.4 | 2.3 | 2 | 3.9 | 1.0 | 4 |
Populations of muscle-resident cells quantified by FACS. Cells were isolated from disaggregated muscle and analysed by FACS in accordance with the scheme presented in Supplementary Figure 1. Frequency is expressed as percentage of cells out of the total live/singlet cell count. Data are presented as mean ± standard error of the mean (SEM), and n numbers are specified in each case. Superscript symbols and underlinings are used to match measurements that are significant between each other.