Table 1.
Signals within HLA associated with IgA susceptibility at the GWAS significance level-P < 5E-08-after imputation of GWAS data.
| SNP | Position in chr 6 (GRCh37) | Reference allele | P | OR [CI 95%] |
|---|---|---|---|---|
| rs9275260 | 32.661.575 | C | 3.42E-09 | 0.56 [0.46–0.68] |
| rs9275259 | 32.661.572 | C | 3.42E-09 | 0.56 [0.46–0.68] |
| rs9275284 | 32.663.073 | C | 4.30E-09 | 0.56 [0.46–0.68] |
| rs9275285 | 32.663.080 | A | 4.30E-09 | 0.56 [0.46–0.68] |
| rs9275286 | 32.663.143 | T | 4.30E-09 | 0.56 [0.46–0.68] |
| rs9275288 | 32.663.203 | A | 4.30E-09 | 0.56 [0.46–0.68] |
| rs9275292 | 32.663.289 | C | 4.30E-09 | 0.56 [0.46–0.68] |
| rs9275244 | 32.660.881 | G | 4.92E-09 | 0.56 [0.46–0.68] |
| rs5000633 | 32.663.610 | C | 5.20E-09 | 0.56 [0.46–0.68] |
| rs2395522 | 32.664.722 | A | 5.25E-09 | 0.56 [0.46–0.68] |
| rs9275279 | 32.662.843 | G | 5.32E-09 | 0.56 [0.46–0.68] |
| rs9275281 | 32.662.920 | G | 5.32E-09 | 0.56 [0.46–0.68] |
| rs4248168 | 32.659.743 | G | 5.46E-09 | 0.56 [0.47–0.68] |
| rs9275224 | 32.659.878 | A | 5.46E-09 | 0.56 [0.47–0.68] |
| rs4713580 | 32.659.994 | C | 5.46E-09 | 0.56 [0.47–0.68] |
| rs4713584 | 32.660.237 | C | 5.46E-09 | 0.56 [0.47–0.68] |
| rs9275225 | 32.660.262 | G | 5.46E-09 | 0.56 [0.47–0.68] |
| rs5002704 | 32.659.279 | T | 5.67E-09 | 0.56 [0.46–0.68] |
| rs4713581 | 32.660.023 | T | 6.08E-09 | 0.56 [0.47–0.68] |
| rs4713583 | 32.660.153 | T | 6.08E-09 | 0.56 [0.47–0.68] |
| rs9275228 | 32.660.347 | G | 6.12E-09 | 0.56 [0.47–0.68] |
| rs9275227 | 32.660.337 | C | 6.12E-09 | 0.56 [0.47–0.68] |
| rs9275295 | 32.663.391 | A | 6.19E-09 | 0.56 [0.46–0.68] |
| rs9275277 | 32.662.677 | G | 7.33E-09 | 0.57 [0.47–0.69] |
| rs9275276 | 32.662.676 | T | 7.33E-09 | 0.57 [0.47–0.69] |
| rs9275245 | 32.660.943 | A | 7.89E-09 | 0.57 [0.47–0.69] |
| rs5002708 | 32.659.357 | T | 8.00E-09 | 0.57 [0.47–0.69] |
| rs5002707 | 32.659.337 | T | 8.00E-09 | 0.57 [0.47–0.69] |
| rs67838634 | 32.662.128 | G | 8.89E-09 | 1.76 [1.45–2.13] |
| rs9275222 | 32.659.516 | T | 1.28E-08 | 1.75 [1.44–2.12] |
| rs6457617 | 32.663.851 | C | 1.44E-08 | 0.57 [0.47–0.70] |
| rs6457620 | 32.663.999 | G | 1.44E-08 | 0.57 [0.47–0.70] |
| rs5002702 | 32.659.158 | G | 1.47E-08 | 0.57 [0.47–0.70] |
| rs9275226 | 32.660.311 | C | 1.49E-08 | 0.57 [0.47–0.70] |
| rs9275230 | 32.660.442 | A | 1.49E-08 | 0.57 [0.47–0.70] |
| rs5002705 | 32.659.319 | C | 1.60E-08 | 0.57 [0.47–0.70] |
| rs4713582 | 32.660.051 | T | 1.63E-08 | 0.57 [0.47–0.70] |
| rs4711304 | 32.660.170 | T | 1.65E-08 | 0.58 [0.47–0.70] |
| rs9275246 | 32.661.003 | C | 2.11E-08 | 0.58 [0.48–0.70] |
| rs4713587 | 32.659.535 | G | 2.36E-08 | 0.58 [0.48–0.70] |
| rs9275247 | 32.661.015 | T | 2.87E-08 | 0.58 [0.48–0.70] |
| rs9275231 | 32.660.505 | C | 2.81E-08 | 1.73 [1.42–2.09] |
HLA: Human leukocyte antigen; IgA: Immunoglobulin-A; GWAS: genome-wide association study; SNP: single nucleotide polymorphism; chr: chromosome; OR: odds ratio; CI: confidence interval.