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. 2017 Jul 11;7:5093. doi: 10.1038/s41598-017-04108-7

Table 1.

Structure, LogP, enzyme inhibition activity against PknB, anti-tuberculosis activity, and selectivity of IMB-YH-8.

Compound Structure LogP a PknB IC50 (μM) H37Rv MIC (μg/ml) THP-1 cell CC50 (μg/ml) SIb
IMB-YH-8 graphic file with name 41598_2017_4108_Figa_HTML.gif 2.022 20.2 0.25 7.61 30.4

aLogP determined with Discovery Studio 2.5. bSI, selectivity index, calculated as the CC50/MIC.