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Structure, LogP, enzyme inhibition activity against PknB, anti-tuberculosis activity, and selectivity of IMB-YH-8.
| Compound | Structure | LogP a | PknB IC50 (μM) | H37Rv MIC (μg/ml) | THP-1 cell CC50 (μg/ml) | SIb |
|---|---|---|---|---|---|---|
| IMB-YH-8 |
|
2.022 | 20.2 | 0.25 | 7.61 | 30.4 |
aLogP determined with Discovery Studio 2.5. bSI, selectivity index, calculated as the CC50/MIC.
