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. 2017 Jul 11;7:5086. doi: 10.1038/s41598-017-05344-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Subgroup analyses for extended dataset. Horizontal lines represent the 95% CIs for the data. The summarized effects (D) are considered statistically significant when their 95% CIs do not cross zero. We used a random-effect model (filled circles) whether heterogeneity was observed, while the fixed-effect model was applied in the absence of heterogeneity (filled squares). Included moderators for the extended data set are: strain (Sprague Dawley, Wistar), sex (male, female), offspring age at testing (young adult), maternal age (young adult), intervention timing [perinatal (gestation and lactation) vs. restricted to gestation period], maternal body weight (increased, not increased), birthweight (decreased, increased, not different), and main fat source (animal, vegetal, mixed; extended dataset). Subgroup analyses for HDL-c extended dataset is available in Supplementary Fig. S4. Subgroup analysis of subsets where heterogeneity was not significant was not performed (SBP subset). Abbreviations: n: number of data points, SD: Sprague Dawley, YA: Young Adult, GES: gestation period only, GES + LAC: gestation and suckling periods.