Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 11;7:5157. doi: 10.1038/s41598-017-05358-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Young mice (2–3 months old) exhibit distinct electrophysiological properties in dorsal, intermediate and ventral dentate gyrus. (a) Image of a dorsal (top) and ventral (bottom) hippocampal slice positioned simultaneously on the multi-electrode array (MEA), zoomed in on the dentate gyrus. Selected stimulation electrodes (triangles) target the medial perforant path. Recording channels of interest (circles) are also indicated. (b) Input/output relationships of dorsal (n = 9), intermediate (n = 6) and ventral (n = 6) hippocampal slices indicate that basal synaptic transmission gradually decreases along the dorsoventral axis. (c) High-frequency stimulation (HFS; four trains of 1 s duration at 100 Hz) in dorsal (n = 9), intermediate (n = 8) and ventral (n = 6) slices induces LTP with a higher magnitude and distinct induction and decay kinetics in the ventral compared to intermediate and dorsal DG. Inset shows representative traces of field excitatory postsynaptic potential (fEPSP) for baseline, 20 min post-HFS and 180 min post-HFS, as indicated by numbers 1–3. 10 μM picrotoxin was added to the ACSF after baseline and until the end of HFS, as indicated by the bar. The grey lines superimposed on the data points denote the best-fitted functions for the induction of potentiation and subsequent decay. See Supplementary Table S1 for all equation parameters. Two-way RM-ANOVA was used for statistical analysis (** indicates p < 0.01 and *** indicates p < 0.001).