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. 2017 Jul 11;7:5157. doi: 10.1038/s41598-017-05358-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distinct electrophysiological properties in dorsal and ventral dentate gyrus of young (a–c) and middle-aged (d–f) mice. (a,d) Input/output curves show a dorsoventral gradient in young (sample sizes: dorsal = 11, ventral = 10) but not in middle-aged mice (dorsal = 9, ventral = 7). (b,e) Paired-pulse ratios are similar between dorsal and ventral DG, both in young (dorsal = 11, ventral = 9) and middle-aged mice (dorsal = 9, ventral = 7). (c) Long-term potentiation in young mice (dorsal = 7, ventral = 9) is characterized by dorsoventral variation in both the induction and maintenance phase. (f) In middle-aged mice (dorsal = 8, ventral = 6), only the induction phase shows dorsoventral differences, whereafter the curves of dorsal and ventral LTP rapidly converge. Representative signal traces are shown for baseline, 20 min post-HFS and 180 min post-HFS, as indicated by numbers 1–3. In this series of recordings, no picrotoxin was used. The grey lines superimposed on the data points represent the best-fitted functions for the induction and decay phases. See Supplementary Tables S2 and S3 for all equation parameters. RM-ANOVA was used for statistical analysis (* indicates p < 0.05 and ** indicates p < 0.01).