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. 2017 Jul 11;7:5157. doi: 10.1038/s41598-017-05358-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Picrotoxin (PTX) has a stronger potentiating effect on the ventral dentate gyrus in young mice (2–3 months old). (a) Levels of potentiation obtained at 20 and 180 min after the start of HFS, for dorsal and ventral slices, with or without the addition of PTX to the recording solution during induction (as can be derived from Figs 1c and 2c, respectively). (b) Comparison of mean ventral/dorsal ratios, calculated based on all possible ratios, for both conditions at 20 and 180 min. Unpaired t tests with Welch’s correction were used for statistical comparisons (** indicates p < 0.01 and *** indicates p < 0.001).