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. 2017 Jul 11;7:5157. doi: 10.1038/s41598-017-05358-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Whole-cell patch-clamp recordings reveal differences in inhibitory properties between dorsal and ventral DG granule cells. (a) Representative traces of miniature inhibitory postsynaptic currents (mIPSCs) of granule cells in slices from dorsal (blue) and ventral (red) hippocampus. (b) Cumulative probability curves indicate significantly shorter median inter-event intervals, i.e. a higher frequency of mIPSCs, in the ventral (409 ms) compared to dorsal DG (524 ms). (c) In contrast, the median mIPSC amplitudes are not different (dorsal: 26.6 pA, ventral: 26.9 pA). (d) Tonic currents in dorsal and ventral granule cells, calculated as the difference between the holding current in the absence and presence of 50 mM bicuculline, are almost identical (dorsal: 12.6 ± 1.5 pA, ventral: 12.2 ± 1.4 pA).