Table 2.
Baseline parameters predictive of the onset of simple steatosis at 3 years, examined using multiple logistic regression.
| Baseline variables | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 |
|---|---|---|---|---|---|
| Age (years) | 1.028 (0.990–1.068) | 1.025 (0.987–1.065) | 1.034 (0.993–1.076) | 1.024 (0.990–1.058) | 1.020 (0.985–1.057) |
| Gender | 2.154 (0.907–5.116) | 1.985 (0.817–4.819) | 2.210 (0.907–5.388) | 3.015 (1.254–7.250)* | 2.454 (1.048–5.744)* |
| BMI (kg/m2) | 1.345 (1.079–1.677)* | 1.324 (1.058–1.656)* | 1.394 (1.109–1.754)* | 1.304 (1.056–1.609)* | 1.314 (1.069–1.614)* |
| Waist circumference (cm) | 1.037 (0.956–1.124) | 1.042 (0.960–1.131) | 1.025 (0.944–1.114) | 1.060 (0.982–1.144) | 1.060 (0.983–1.142) |
| SBP (mmHg) | 0.968 (0.936–1.002) | 0.966 (0.933–1.001) | 0.969 (0.937–1.003) | 0.975 (0.944–1.007) | 0.977 (0.947–1.009) |
| DBP (mmHg) | 1.068 (1.009–1.130)* | 1.076 (1.015–1.141)* | 1.069 (1.010––.131)* | 1.057 (1.001–1.117)* | 1.054 (0.999–1.113) |
| ALT (IU/L)§ | 1.787 (0.495–6.450) | 1.854 (0.498–6.905) | 1.962 (0.529–7.278) | 2.053 (0.584–7.215) | 1.405 (0.413–4.774) |
| AST (IU/L)§ | 0.613 (0.075–5.029) | 0.707 (0.082–6.081) | 0.735 (0.088–6.121) | 0.569 (0.080–4.053) | 0.628 (0.083–4.767) |
| GGT (IU/L)§ | 0.977 (0.432–2.210) | 0.847 (0.359–1.996) | 0.821 (0.353–1.912) | 1.150 (0.522–2.535) | 1.024 (0.465–2.257) |
| TC (mmol/L) | 1.086 (0.490–2.408) | 1.173 (0.514–2.675) | 1.153 (0.520–2.558) | 1.207 (0.540–2.697) | 1.191 (0.547–2.593) |
| TG (mmol/L)§ | 1.112 (0.411–3.008) | 0.960 (0.342–2.696) | 1.007 (0.366–2.772) | 0.925 (0.343–2.494) | 1.192 (0.455–3.119) |
| HDL-C (mmol/L) | 0.696 (0.120–4.034) | 0.566 (0.092–3.492) | 0.799 (0.136–4.707) | 0.434 (0.076–2.474) | 0.631 (0.117–3.398) |
| LDL-C (mmol/L) | 0.882 (0.407–1.909) | 0.814 (0.365–1.814) | 0.833 (0.385–1.804) | 0.833 (0.378–1.834) | 0.870 (0.408–1.852) |
| FPG (mmol/L) | 0.811 (0.524–1.253) | 1.075 (0.517–2.237) | 0.790 (0.505–1.236) | 0.735 (0.484–1.117) | 0.746 (0.496–1.123) |
| 2hPG (mmol/L) | 1.122 (0.963–1.308) | 1.117 (0.962–1.296) | 1.114 (0.954–1.301) | 1.165 (1.007–1.348)* | 1.151 (0.998–1.328) |
| HOMA-beta§ | / | 1.712 (0.482–6.085) | / | / | / |
| HOMA-IR§ | / | 0.807 (0.203–3.204) | / | / | / |
| Adiponectin§ | / | / | 0.622 (0.319–1.212) | / | / |
| FGF21 (pg/ml)§ | 1.814 (1.063–3.096)* | 1.861 (1.078–3.213)* | 1.881 (1.096–3.228)* | / | / |
| CK18 M30 (U/L)§ | / | / | / | 0.665 (0.370–1.197) | / |
| CK18 M65ED (U/L)§ | / | / | / | / | 1.211 (0.689–2.128) |
Data are odds ratio (OR) (95%CI).
§Ln transformed before analysis. *P < 0.05.
Model 1. Included baseline risk factors (age, gender, BMI, waist circumference, SBP, DBP, ALT, AST, GGT, TG, TG, HDL-C, LDL-C, FPG and 2hPG), and FGF21.
Model 2 Included baseline risk factors, HOMA-beta, HOMA-IR, and FGF21.
Model 3 Included baseline risk factors, adiponectin, and FGF21.
Model 4 Included baseline risk factors and CK18 M30.
Model 5 Included baseline risk factors and CK18 M65ED.